Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain
Jessica L. Fletcher, Rhiannon J. Wood, Jacqueline K. Nguyen, Eleanor M. L. Norman, Christine M.K. Jun, Alexa R Prawdiuk, Melissa Biemond, Huynh T.H. Nguyen, Susan E. Northfield, Richard A Hughes, David G. Gonsalvez, Junhua Xiao, Simon S. Murray
This study shows that a BDNF mimetic targeting TrkB promotes myelin repair in a mouse model of demyelination by enhancing oligodendrocyte differentiation and remyelination.
Journal of Neuroscience · Jul 5, 2018Peer-reviewedNeuroscience