AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification
LeeAnn A. Hold, Nicole Migotsky, Syeda N. Lamia, Steph S. Steltzer, Sydney Grossman, Jessica A. Chen, Seung-Ho Bae, Paige Cordts, Tessa Phillips, Matthew J. O’Meara, Carol S. Davis, Susan V. Brooks, Moeed Akbar, Neal L. Millar, Megan Leigh Killian, Adam C. Abraham
This study shows AMPK1 is essential for tendon health, preventing senescence and calcification through metabolic regulation and ECM remodeling.
bioRxiv · Jan 31, 2025 · PreprintPathology