Nicole Migotsky

The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a (Hif1a) during postnatal development

This study shows that the postnatal tendon enthesis remains hypoxic and requires Hif1a for cell survival, ECM organization, and structural integrity.

Protocol for 3D digital dynamic histomorphometry of bone via time-lapse registration of serial microCT scans

This paper describes a protocol using microCT scans and Dragonfly for quantifying bone remodeling in rodents over time without coding expertise.

Combination Treatment with Sclerostin and Dkk1 Antibodies Synergizes with Tibial Loading to Stimulate Bone Formation in Aged Mice

This study shows that combining Sclerostin and Dkk1 antibodies with mechanical loading significantly enhances bone formation in aged mice.

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

Functional Changes to Achilles Tendon and Enthesis in a Mouse Model of an Adolescent Masculine Gender-Affirming Hormone Treatment

This study examines how puberty suppression and testosterone affect Achilles tendon and enthesis properties in a mouse model of transmasculine gender-affirming hormone therapy, finding improved load capacity and increased cell density with GnRHa treatment.

AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification

This study shows AMPK1 is essential for tendon health, preventing senescence and calcification through metabolic regulation and ECM remodeling.

Spatial histomorphometry reveals that local peripheral nerves modulate but are not required for skeletal adaptation to applied load in mice

Multi-Scale Cortical Bone Traits Vary in Two Mouse Models of Genetic Diversity

This study examines how genetic diversity affects multi-scale cortical bone traits in two mouse populations, finding significant heritability and hybrid phenotypes in outbred mice.

Osteoblast-Specific Wnt Secretion is Required for Skeletal Homeostasis and Loading-Induced Bone Formation in Adult Mice

This study shows that osteoblast-specific Wnt secretion is essential for maintaining bone homeostasis and the anabolic response to mechanical loading in adult mice.