This study examines how puberty suppression and testosterone affect Achilles tendon and enthesis properties in a mouse model of transmasculine gender-affirming hormone therapy, finding improved load capacity and increased cell density with GnRHa treatment.

Connective Tissue Research · Feb 28, 2025Peer-reviewedPhysiology

Candida auris skin colonization is mediated by Als4112 and interactions with host extracellular matrix proteins

Guolei Zhao, Jingwen Lyu, Natalia A. Veniaminova, Robert Żarnowski, Eliciane Cevolani Mattos, Chad J Johnson, Derek Quintanilla, Haley Hautau, LeeAnn A. Hold, Bin Xu, Juliet A. E. Anku, Steph S. Steltzer, Kaustav Das Gupta, Darian J. Santana, Ashraf S. Ibrahim, , Teresa R. O’Meara

This study identifies Als4112 as critical for Candida auris skin colonization and explores collagen coatings to prevent adherence.

bioRxiv · Feb 13, 2025 · PreprintMicrobiology

AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification

LeeAnn A. Hold, Nicole Migotsky, Syeda N. Lamia, Steph S. Steltzer, Sydney Grossman, Jessica A. Chen, Seung-Ho Bae, Paige Cordts, Tessa Phillips, Matthew J. O’Meara, Carol S. Davis, Susan V. Brooks, Moeed Akbar, Neal L. Millar, Megan Leigh Killian, Adam C. Abraham

This study shows AMPK1 is essential for tendon health, preventing senescence and calcification through metabolic regulation and ECM remodeling.

bioRxiv · Jan 31, 2025 · PreprintPathology