Spatial Profiling Reveals Equivalence-Derived Molecular Signatures of Brain Mimicry and Adaptation in Breast Cancer Brain Metastases
Maxine C. Umeh-Garcia, Christine Y. Yeh, Bryanna Godfrey, Pablo Nunez Perez, Giuseppe Barisano, Sushama Varma, Saman Seyed Ahmadian, Angus Martin Shaw Toland, Monica Granucci, Thy Trang Hoang Trinh, Hannes S. Vogel, Robert B. West, Michael Angelo, Lü Tian, Sylvia K. Plevritis, Melanie Hayden Gephart
This study identifies molecular signatures of brain mimicry and adaptation in breast cancer brain metastases using spatial transcriptomic profiling and a new algorithm called Equivalent Expression Index.
bioRxiv · Jan 13, 2025 · PreprintCancer Biology