Melanie Hayden Gephart

The paper identifies progranulin as a mediator of immune suppressive niches in brain metastasis using cross-species spatial transcriptomics and functional analyses.

CSF-Seq profiles cerebrospinal fluid transcriptomes to identify a prognostic gene signature for leptomeningeal disease.

The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.

This study analyzes multi-omic data from gliomas to identify therapeutic escape mechanisms and TME evolution, finding that N-glycosylation classifies tumor grade and immune transcriptome predicts GBM survival.

This study identifies the immunosuppressive cellular and genomic features of colorectal cancer brain metastases and their mechanisms of adaptation.

This study analyzes DNA fragmentation and methylation in CSF-derived cfDNA from NSCLC-BMET patients and finds distinct patterns compared to controls and plasma-derived cfDNA.

This study identifies molecular signatures of brain mimicry and adaptation in breast cancer brain metastases using spatial transcriptomic profiling and a new algorithm called Equivalent Expression Index.

This study compares mutation frequencies between leptomeningeal and solid lung cancer brain metastases, finding higher EGFR mutations in leptomeningeal disease and no KRAS mutations.

This study uses single-cell RNAseq to analyze infiltrating neoplastic cells in human glioblastoma, identifying consistent gene signatures and distinct myeloid cell populations across patients.