Robert B. West

This study evaluates Atera, a spatial transcriptomics platform, showing its ability to resolve clonal cancer evolution and immune response in situ using DCIS samples.

The paper identifies ECM proteomic signatures associated with disease-free survival in DCIS and IBC, showing reduced collagen peptides correlate with poorer outcomes.

Prostate-TriMod integrates visual morphology, spatial tissue maps, and clinical outcomes for prostate cancer to enable multimodal AI research.

The paper develops TOPAZ, a tool that predicts cancerous cells/glands and analyzes immune cell spatial relationships in prostate cancer, finding that immune cell distance from cancer glands correlates with recurrence risk.

TissueViewer is a web-based tool for viewing large multiplexed image datasets from spatial biology techniques efficiently over the internet.

This study shows that swirling motion of breast cancer cells aligns collagen fibers radially, enabling collective invasion by generating contractile stresses.

This study identifies molecular signatures of brain mimicry and adaptation in breast cancer brain metastases using spatial transcriptomic profiling and a new algorithm called Equivalent Expression Index.

QUICHE identifies low-prevalence cellular niches in spatial datasets, outperforming existing methods, and reveals structural anti-tumor immune responses in TNBC.

This study identifies a four amino acid motif in VISTA that suppresses tumor growth by altering EGFR signaling through NUMB recruitment.

FML-seq reduces costs of DNA methylation profiling while maintaining accuracy in measuring absolute and differential cytosine methylation in human cell lines.

This paper introduces RNA-GAN, a deep generative model that creates synthetic whole-slide image tiles using gene expression profiles, outperforming traditional GANs and showing imputation capabilities.

This paper introduces Smart-3SEQ, a method for accurate gene expression profiling from small RNA samples, including FFPE tissue, and demonstrates its application to identify new macrophage phenotypes in the tumor microenvironment.