Reconstruction of Contemporary Human Stem Cell Dynamics with Oscillatory Molecular Clocks
Calum Gabbutt, Ryan O. Schenck, Daniel J. Weisenberger, Christopher Kimberley, Alison Berner, Jacob Househam, Eszter Lakatos, Mark Robertson‐Tessi, Isabel Rodríguez Martín, Roshani Patel, Susan K. Clark, Andrew R. Latchford, Chris P. Barnes, Simon John Leedham, Alexander R.A. Anderson, , Darryl K. Shibata
The paper introduces rapidly oscillating molecular clocks to quantify human stem cell dynamics and finds differences in stem cell replacement rates between small intestine and colon, as well as effects of germline mutations.
Nature Biotechnology · Jan 3, 2022Peer-reviewedBioinformatics