Cell-cycle dependent inhibition of BRCA1 signaling by the lysine methyltransferase SET8
Yannick Perez, Fatima Alhourani, Julie Patouillard, Cyril Ribeyre, Marion Larroque, Véronique Baldin, David Llères, Charlotte Grimaud, Eric Julien
This study shows SET8 inhibits BRCA1 signaling during S-phase by promoting 53BP1 accumulation, and its degradation is essential for BRCA1 and RAD51 complex nuclear focal accumulation.
Cell Cycle · Feb 16, 2025Peer-reviewedMolecular Biology