Molecular BiologyCell CyclePeer-reviewed
Cell-cycle dependent inhibition of BRCA1 signaling by the lysine methyltransferase SET8
Yannick Perez, Fatima Alhourani, Julie Patouillard…·Eric Julien
This study shows SET8 inhibits BRCA1 signaling during S-phase by promoting 53BP1 accumulation, and its degradation is essential for BRCA1 and RAD51 complex nuclear focal accumulation.