The orthobunyavirus Gc glycoprotein head and stalk drives an infectious virion assembly pathway that is specific for the insect host
Amelia B. Shaw, Hiu Nam Tse, Molly V. Durawa, Owen Byford, Hayley M. Pearson, Kenneth A. Stapleford, Juan Fontana, John N. Barr
This study shows that the Gc glycoprotein head and stalk domains are essential for virion assembly in insect hosts but not in mammalian cells, explaining their conservation in nature.
bioRxiv · Nov 18, 2025 · PreprintMicrobiology