Juan Fontana

Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b

This study determines the structure of herpes simplex virus 2 glycoprotein C interacting with C3b, revealing a unique mechanism to modulate the complement cascade.

Interaction of Bunyamwera Virus Non-Structural Protein NSm with Cellular BNIP1 is Required for Efficient Viral Gene Expression and Replication

This study identifies BNIP1 as a host factor required for Bunyamwera virus replication, showing its interaction with NSm and dependence on COPI vesicle trafficking.

Constructive neutral evolution explains the emergence of specialised ribosomes in diverse eukaryotes.

This study shows that ribosome specialisation in eukaryotes arises through constructive neutral evolution, not adaptation or selection.

Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome

This paper investigates the role of the N-terminal domain of the capsid protein in calicivirus assembly and stability, showing its interaction with the viral genome and its impact on capsid structure and mechanical properties.

Adhirons are efficient tools to guide antiviral ligand discovery

This study develops a pipeline using Adhirons to guide small molecule discovery against viral targets, identifying hits for Crimean-Congo Haemorrhagic Fever Virus and Influenza A Virus.

The orthobunyavirus Gc glycoprotein head and stalk drives an infectious virion assembly pathway that is specific for the insect host

This study shows that the Gc glycoprotein head and stalk domains are essential for virion assembly in insect hosts but not in mammalian cells, explaining their conservation in nature.

The architecture of membrane structures involved in hepatitis C virus genome replication revealed in close-to-native conditions by cryo-electron tomography

This study uses cryo-electron tomography to visualize HCV replication structures in near-native conditions, revealing densities within membranous vesicles that may represent viral replication machinery.

Interactions between the 2C protein of FMDV and components of the viral replication machinery are mediated by ER-derived membranes

This study identifies interactions between FMDV 2C protein and viral and host factors, revealing ER-derived replication complexes and potential targets for disrupting the FMDV lifecycle.

Translational activity of 80S monosomes varies dramatically across different tissues

The paper examines translational activity of 80S monosomes in different Drosophila tissues, finding that head and embryo monosomes are active while testis and ovary monosomes are inactive.

The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-alpha-inhibitor regulate crosslinking of the hyaluronan matrix

This paper investigates how PTX3's quaternary structure enables HA crosslinking via interactions with HC1, revealing pH-dependent binding and structural flexibility.