Richard J. Beck

Resource limitation rewires chromosome instability and ploidy evolution across in vitro and in vivo cancer models

This study models how resource limitations and chromosomal instability influence ploidy evolution in cancer cells across in vitro and in vivo settings.

Inverse Game Theory Characterizes Frequency-Dependent Selection Driven by Karyotypic Diversity in Triple Negative Breast Cancer

The paper introduces ECO-K, an inverse game theory framework to infer subpopulation interactions from single-cell sequencing data in TNBC, revealing frequency-dependent selection driven by karyotypic diversity.

A longitudinal data framework for context-specific genotype-to-phenotype mapping

The paper introduces CLONEID, a framework for organizing clone-resolved data to enable longitudinal genotype-to-phenotype mapping in experiments with repeated molecular and phenotypic measurements.