Joel S. Brown

This paper develops an evolutionary model to evaluate extinction therapy strategies for cancer, showing it outperforms combination therapy when cross-resistance exists.

The paper introduces ECO-K, an inverse game theory framework to infer subpopulation interactions from single-cell sequencing data in TNBC, revealing frequency-dependent selection driven by karyotypic diversity.

This study proposes integrating migrastatics into adaptive therapy to delay metastasis and improve cancer treatment outcomes.

The paper shows polyaneuploid prostate cancer cells under hypoxia exhibit enhanced motility and aerotaxis driven by HIF-1α and RhoA, enabling invasion and intravasation.

This study combines radiotherapy and NK cell immunotherapy to exploit an evolutionary double-bind strategy in prostate cancer, showing that RT-resistant cells become more vulnerable to NK cell killing.