Vural Tagal

Resource limitation rewires chromosome instability and ploidy evolution across in vitro and in vivo cancer models

This study models how resource limitations and chromosomal instability influence ploidy evolution in cancer cells across in vitro and in vivo settings.

Ploidy shapes gemcitabine response through altered potency and delayed cell death

This study shows that higher ploidy reduces gemcitabine potency and delays cell death by altering drug exposure kinetics and response timing.

A longitudinal data framework for context-specific genotype-to-phenotype mapping

The paper introduces CLONEID, a framework for organizing clone-resolved data to enable longitudinal genotype-to-phenotype mapping in experiments with repeated molecular and phenotypic measurements.

Cell identity revealed by precise cell cycle state mapping links data modalities

The paper integrates sequencing and imaging data to map cell cycle states, linking transcriptome states to living cells with high resolution.