Joyce J. Thompson

The paper shows that disrupting chromatin domain boundaries with multiple developmental regulators can cause severe gene dysregulation and developmental defects in mice.

This study shows that MLL3/MLL4 methyltransferase activities are essential for early embryonic development and stem cell differentiation, but their role is lineage-selective and not dependent on enhancer activation.

The paper shows GATA6 and NANOG bind shared regulatory elements to drive divergent cell fates in mouse blastocysts by modulating chromatin accessibility and transcriptional activation.

The paper characterizes the epigenomic landscape of embryonic mouse forebrain neural progenitors using snATAC-Seq and integrates multi-omics data to reveal region-specific regulatory mechanisms.

This study identifies OTUD5 as essential for chromatin remodeling during development, showing its role in preventing degradation of chromatin regulators and maintaining proper gene expression networks.