Timothy J. Petros

This study investigates the effects of Arx removal in MGE-derived interneurons in mice, revealing altered cellular organization and cortical neurogenesis in both male and female models of X-linked intellectual disability.

This study shows that reducing H3K4 methylation in specific brain regions causes neurodevelopmental disorder-like phenotypes, including seizures, growth issues, and behavioral deficits.

The paper investigates the spatial and temporal origins of interneuron subtypes in the caudal ganglionic eminence (CGE) and shows that specific subtypes arise from distinct CGE subdomains with stable spatial biases over time.

This study uses single-nucleus RNA sequencing to show methamphetamine induces cholesterol metabolism gene upregulation in dopaminergic neurons, with drug-specific effects and potential implications for neuron function.

The paper shows that disrupting chromatin domain boundaries with multiple developmental regulators can cause severe gene dysregulation and developmental defects in mice.

This study shows that loss of Ezh2 in the medial ganglionic eminence (MGE) leads to changes in interneuron fate, morphology, and gene expression.

The paper shows that high affinity enhancer-promoter interactions can bypass CTCF/cohesin insulation and maintain gene expression in some tissues but not others.

The paper characterizes the epigenomic landscape of embryonic mouse forebrain neural progenitors using snATAC-Seq and integrates multi-omics data to reveal region-specific regulatory mechanisms.

This study uses single-cell RNA sequencing to reveal transcriptional heterogeneity in ventricular zone cells of the embryonic mouse forebrain, showing spatial and temporal gene expression differences.

This study identifies Grin1 as a key regulator of subtype-specific gene expression in MGE-derived interneurons, linking NMDAR signaling to neurodevelopmental disorders like schizophrenia.

The paper uses single nucleus RNA sequencing to identify diverse cholinergic neuron types in the adult mouse spinal cord, revealing distinct transcriptomic classes of visceral and skeletal motor neurons.

The paper examines LIS1 mutation effects on PV+INTs in mouse hippocampus, identifying a non-canonical intermediate spiking subset linked to seizures.