An Enhancement of Extrachromosomal Circular DNA Enrichment and Amplification to Address the Extreme Low Overlap Between Replicates
Charles M Burnham, Alongkorn Kurilung, Visanu Wanchai, Birgitte Regenberg, Jesús Delgado‐Calle, Alexei G. Basnakian, Intawat Nookaew
This paper improves eccDNA enrichment and amplification methods, achieving >50% overlap in technical replicates compared to <1% previously observed.
Journal of Biological Chemistry · Feb 20, 2026Peer-reviewedGenomics