Birgitte Regenberg

This paper improves eccDNA enrichment and amplification methods, achieving >50% overlap in technical replicates compared to <1% previously observed.

This study investigates the role of small extrachromosomal circular DNA (eccDNA) in colorectal cancer, finding that it contributes to gene expression, immune cell recruitment, and poor patient outcomes.

The paper develops a method to profile extrachromosomal circular DNA (eccDNA) in plasma and finds higher eccDNA levels in lung adenocarcinoma patients compared to healthy donors.

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

The paper investigates whether extrachromosomal circular DNA (eccDNA) contributes to genome evolution in mammals by analyzing synteny maps across species.

This paper introduces CReSIL 2.0, a software suite for identifying and characterizing extrachromosomal circular DNA from long-read sequences, achieving high accuracy in simulated data.

This study identifies and characterizes over one million urinary cell free eccDNAs in healthy adults, revealing their genomic distribution, sequence features, and potential role of direct repeats in their biogenesis.

Circle-Map improves detection of circular DNA from short-read sequencing data by realigning partially aligned reads using discordantly mapped reads.

This study demonstrates CRISPR/Cas9 can generate extrachromosomal circular DNA and ring chromosomes in human cells, enabling new tools for genetic engineering and disease modeling.