Wilson disease: intersecting DNA methylation and histone acetylation regulation of gene expression in a mouse model of hepatic copper accumulation
Gaurav V. Sarode, Kari E. Neier, Noreene M. Shibata, Yuanjun Shen, Dmitry A. Goncharov, Elena A. Goncharova, Tagreed A. Mazi, Nikhil Joshi, Matthew Lee Settles, Janine M. LaSalle, Valentina Medici
This study investigates how DNA methylation and histone acetylation changes in a mouse model of Wilson disease are influenced by diet and copper chelation, revealing their role in regulating gene expression in metabolic pathways.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2021Peer-reviewedMolecular Biology