The paper investigates how PCB exposure interacts with MeCP2 mutations in female mice, identifying shared gene pathways and transcriptional impacts in the cortex.

iScience · Apr 20, 2026Peer-reviewedSystems Biology

Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment

Aron Judd P. Mendiola, Jennifer M. Rutkowsky, Kari E. Neier, Sophia M. Hakam, Osman Sharifi, Callum George Donnelly, Christina Torres, Cielo Hernandez, Dag H. Yasui, Jon Jay Ramsey, Janine M. LaSalle

The paper examines how Snord116 genotype interacts with light and sex to influence metabolism, behavior, and imprinted gene networks in mice after circadian entrainment.

bioRxiv · May 1, 2025 · PreprintAnimal Behavior & Cognition

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression

Osman Sharifi, Viktoria Haghani, Kari E. Neier, Keith J. Fraga, Ian F. Korf, Sophia M. Hakam, Gerald Quon, Nelson Johansen, Dag H. Yasui, Janine M. LaSalle

The paper identifies sex-specific transcriptomic changes in a mouse model of Rett syndrome, showing more differentially expressed genes in females and non-cell-autonomous effects.

Communications Biology · Oct 9, 2024Peer-reviewedGenetics

Placental-brain axis in females detected within broadly impacted metabolic gene networks protects against prenatal PCB exposure

Kelly H. Chau, Kari E. Neier, Anthony E. Valenzuela, Rebecca J. Schmidt, Blythe P Durbin-Johnson, Pamela J. Lein, Ian F. Korf, Janine M. LaSalle

The paper investigates sex-specific transcriptional responses to prenatal PCB exposure in mouse brain and placenta, finding female protective effects mediated by metabolic gene networks.

bioRxiv · Jul 14, 2024 · PreprintGenomics

The role of intestine in metabolic dysregulation in murine Wilson disease

Gaurav V. Sarode, Tagreed A. Mazi, Kari E. Neier, Noreene M. Shibata, Guillaume Jospin, Nathaniel H. O. Harder, Amanda Caceres, Marie C. Heffern, Ashok Kumar Sharma, Shyam Kailashrao More, Maneesh Dave, Shannon Schroeder, Li Wang, Janine M. LaSalle, Svetlana Lutsenko, Valentina Medici

This study investigates the role of the intestine in metabolic dysregulation in murine Wilson disease by analyzing gut microbiota and lipidome in mouse models.

Hepatology Communications · Sep 11, 2023Peer-reviewedMolecular Biology

Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment

Julia S. Mouat, Xueshu Li, Kari E. Neier, Yihui Zhu, Charles E. Mordaunt, Michele Andrea La Merrill, Hans‐Joachim Lehmler, Michael P. Jones, Pamela J. Lein, Rebecca J. Schmidt, Janine M. LaSalle

The paper identifies placental DNA methylation modules associated with maternal PCB levels and child neurodevelopmental outcomes in the MARBLES cohort.

Environmental Research · Jan 3, 2023Peer-reviewedGenetic & Genomic Medicine

Genome-Wide DNA Methylation Profiles of Neurodevelopmental Disorder Genes in Mouse Placenta and Fetal Brain Following Prenatal Exposure to Polychlorinated Biphenyls

Benjamin I. Laufer, Kari E. Neier, Anthony E. Valenzuela, Dag H. Yasui, Rebecca J. Schmidt, Pamela J. Lein, Janine M. LaSalle

This study examines DNA methylation changes in mouse placenta and fetal brain after prenatal PCB exposure, finding shared differentially methylated regions linked to neurodevelopmental disorders.

Cell Reports · Mar 1, 2022Peer-reviewedGenomics

Wilson disease: intersecting DNA methylation and histone acetylation regulation of gene expression in a mouse model of hepatic copper accumulation

Gaurav V. Sarode, Kari E. Neier, Noreene M. Shibata, Yuanjun Shen, Dmitry A. Goncharov, Elena A. Goncharova, Tagreed A. Mazi, Nikhil Joshi, Matthew Lee Settles, Janine M. LaSalle, Valentina Medici

This study investigates how DNA methylation and histone acetylation changes in a mouse model of Wilson disease are influenced by diet and copper chelation, revealing their role in regulating gene expression in metabolic pathways.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2021Peer-reviewedMolecular Biology

Perinatal exposure to lead results in altered DNA methylation in adult mouse liver and blood: Implications for target versus surrogate tissue use in environmental epigenetics

Laurie Kathleen Svoboda, Kari E. Neier, R Cavalcante, Zing Tsung‐Yeh Tsai, TR Jones, S Liu, JM Goodrich, Claudia Lalancette, Justin A. Colacino, MA Sartor, Dana C. Dolinoy

This study shows perinatal lead exposure causes sex-specific DNA methylation changes in adult mouse liver and blood, with some methylation sites overlapping between tissues.

bioRxiv · Oct 2, 2019 · PreprintGenomics