Janine M. LaSalle

The paper investigates how PCB exposure interacts with MeCP2 mutations in female mice, identifying shared gene pathways and transcriptional impacts in the cortex.

Rocketchip improves rigor and reproducibility in ChIP-seq, CUT&RUN, and CUT&Tag data analysis by enabling comparison and swapping of analysis components.

This study investigates the effects of excess prenatal folic acid on mouse brain transcriptome and methylome, revealing altered gene expression and electrophysiological changes.

The paper examines how Snord116 genotype interacts with light and sex to influence metabolism, behavior, and imprinted gene networks in mice after circadian entrainment.

This study identifies sex-specific DNA methylation signatures of autism spectrum disorder in newborn blood, showing replication and enrichment for ASD-risk genes and neurodevelopmental processes.

The paper identifies sex-specific transcriptomic changes in a mouse model of Rett syndrome, showing more differentially expressed genes in females and non-cell-autonomous effects.

The paper integrates CTCF loops, methylome, and transcriptome data from LUHMES neurons to study imprinting dynamics at the 15q11-q13 locus during differentiation.

The paper investigates sex-specific transcriptional responses to prenatal PCB exposure in mouse brain and placenta, finding female protective effects mediated by metabolic gene networks.

The paper identifies sex-specific DNA methylation differences in newborns with Down syndrome and major congenital heart defects compared to those without defects.

This study investigates the role of the intestine in metabolic dysregulation in murine Wilson disease by analyzing gut microbiota and lipidome in mouse models.

The paper identifies placental DNA methylation modules associated with maternal PCB levels and child neurodevelopmental outcomes in the MARBLES cohort.

The paper identifies methylation changes in cell-free fetal DNA linked to maternal obesity and correlates them with infant brain and behavioral outcomes in macaques.

This study examines the association between exposure to DDE and DNA methylation patterns in sperm, finding enriched ASD risk genes and neurodevelopmental pathways.

This study examines DNA methylation changes in mouse placenta and fetal brain after prenatal PCB exposure, finding shared differentially methylated regions linked to neurodevelopmental disorders.

Comethyl identifies modules of comethylated genomic regions correlated with sample traits, revealing ASD-associated modules in cord blood samples.

This study identifies long-term epigenetic changes in rhesus macaques exposed to wildfire smoke during early life, showing methylation differences and gene expression changes linked to immune and nervous system processes.

This study overexpresses DNMT3L in SH-SY5Y neurons and shows it recreates aspects of the DS DNA methylation signature through hypermethylation and hypomethylation of specific genomic regions.

This study investigates how DNA methylation and histone acetylation changes in a mouse model of Wilson disease are influenced by diet and copper chelation, revealing their role in regulating gene expression in metabolic pathways.

The paper examines gene expression and metabolite associations in maternal blood during pregnancy to link prenatal nutrition with neurodevelopmental outcomes in children.

The paper identifies DNA methylation differences in cord blood samples from newborns later diagnosed with ASD, revealing sex-specific epigenomic signatures linked to neurodevelopmental and X-linked genes.

The paper uses low-pass whole genome bisulfite sequencing on neonatal dried blood spots to identify DNA methylation differences in Down syndrome, highlighting RUNX1 hypermethylation and its association with congenital heart disease.

The paper integrates RNA-Seq datasets to identify key splicing factors in diseases and biological processes using signature comparison analysis.

The paper shows BTBR mouse genetic variants lead to altered chromatin accessibility and hyper-responsive innate immunity in macrophages, linking genetic differences to ASD-related immune abnormalities.

This study identifies ASD-specific transcriptional changes in umbilical cord blood through a meta-analysis of two high-risk cohorts, highlighting environmental, immune, and epigenetic factors.

This paper investigates the molecular impacts of UBE3A loss in a novel rat model of Angelman syndrome using systems biology approaches, revealing epigenetic network interactions between maternal and paternal transcripts.

The paper identifies epigenomic signatures in NDD cortex samples, revealing shared regulatory functions and enrichment for genetic risk factors across different NDD types.

The paper identifies 3,152 differentially methylated regions in DS brain tissue using WGBS, revealing hypermethylation in key biological pathways and cross-tissue concordance for hypermethylated regions.

The paper identifies two placental DNA methylation markers, CYP2E1 and IRS2, associated with ASD risk and modulated by genetic and environmental factors.

This study shows that MeCP2-e1 mutation in mice reproduces motor and metabolic issues seen in Rett syndrome patients.

This study shows that Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN, and exogenous expression alone cannot rescue the genetic deficiency of Snord116 paternal deletion.