Author

James Butcher

University of OttawaORCID 0000-0002-7050-1834Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:metagenomics· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alain P. StintziiD· 2 shared Caitlin M. A. SimopoulosiD· 2 shared Daniel FigeysiD· 2 shared Janice MayneiD· 2 shared Leyuan LiiD· 2 shared Xu ZhangiD· 2 shared Zhibin NingiD· 2 shared David R. MackiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMicrobiology

Alain P. StintziORCID

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2 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedOct 23, 2025

Systematic Metaproteomics Mapping Reveals Functional and Ecological Landscapes of Ex Vivo Human Gut Microbiota Responses to Therapeutic Drugs

Leyuan Li, Caitlin M. A. Simopoulos, Janice Mayne…·Daniel Figeys

This study maps metaproteomic responses of human gut microbiota to 312 drugs, identifying 47 compounds that significantly alter microbial protein profiles and reveal functional state shifts.

11 citations

humanmetagenomics

𝕏 PostBluesky

Systems BiologybioRxivPreprintJul 15, 2021

Revealing Protein-Level Functional Redundancy in the Human Gut Microbiome using Ultra-deep Metaproteomics

Leyuan Li, Zhibin Ning, Xu Zhang…·Daniel Figeys

This study quantifies protein-level functional redundancy in the human gut microbiome using ultra-deep metaproteomics and network analysis, revealing high redundancy and environmental influences on functional organization.

4 citations

humanmetagenomics

𝕏 PostBluesky