Author

Lefeng Wang

Sir Run Run Shaw HospitalORCID 0000-0002-7061-3385Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Huanan WangiD· 2 shared Kun ZhangiD· 2 shared Lei LuoiD· 2 shared Panpan ZhaoiD· 2 shared Shaohua WangiD· 2 shared Shuang LiiD· 2 shared Yan ShiiD· 2 shared Yanna DangiD· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersDevelopmental Biology

Huanan WangORCID

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2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintSep 11, 2021

The histone deacetylase activity of HDAC1/2 is required to safeguard zygotic genome activation in mice and cattle

Yanna Dang, Shuang Li, Panpan Zhao…·Kun Zhang

This study shows HDAC1/2 activity is essential for zygotic genome activation in mice and cattle by regulating histone modifications and gene expression during early development.

4 citations

mousebacteria (other)

Developmental BiologyEpigeneticsPeer-reviewedSep 19, 2019

Essential roles of Hdac1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

Panpan Zhao, Huanan Wang, Han Wang…·Kun Zhang

This study shows that co-knockdown of Hdac1 and 2 causes developmental failure in mouse embryos due to impaired lineage specification, increased apoptosis, and altered DNA methylation.

34 citations

mouseDNA methylation