Yanna Dang

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

This study shows p300/CBP acetylation is essential for minor zygotic genome activation by enabling DUX expression and Pol II pre-configuration at ZGA gene promoters.

This study uses base editing in bovine embryos to show that SOX2 has species-specific roles in pluripotency regulation, differing from its function in mice.

This study shows that H1FOO is essential for bovine preimplantation development by regulating lineage specification and nucleosome assembly, with its depletion causing developmental arrest and chromatin structure changes.

The paper maps H3K4me3 histone modifications in bovine oocytes and embryos, showing dynamic changes and functional roles in development.

This study shows HDAC1/2 activity is essential for zygotic genome activation in mice and cattle by regulating histone modifications and gene expression during early development.

This study shows that co-knockdown of Hdac1 and 2 causes developmental failure in mouse embryos due to impaired lineage specification, increased apoptosis, and altered DNA methylation.