Huanan Wang

This study develops mechanochemically reprogrammed stem cell exosomes that enhance immunomodulatory function and macrophage uptake for pulmonary fibrosis therapy.

This study uses AI to analyze hydrogel microenvironments and identifies matrix stiffness as key for enhancing MSC immunomodulation.

This study uses base editing in bovine embryos to show that SOX2 has species-specific roles in pluripotency regulation, differing from its function in mice.

This study shows HDAC1/2 activity is essential for zygotic genome activation in mice and cattle by regulating histone modifications and gene expression during early development.

This study shows that co-knockdown of Hdac1 and 2 causes developmental failure in mouse embryos due to impaired lineage specification, increased apoptosis, and altered DNA methylation.