Yan Shi

p300/CBP-catalyzed acetylation safeguards minor zygotic genome activation via activating DUX

This study shows p300/CBP acetylation is essential for minor zygotic genome activation by enabling DUX expression and Pol II pre-configuration at ZGA gene promoters.

The Role and Mechanism of TEAD4 in Preimplantation Embryonic Development in Mice and Cattle

This study investigates the role of Tead4 in mouse and bovine preimplantation development, finding it essential for blastocyst formation and regulating key genes like Krt8 and Yap.

Base editing in bovine embryos reveals a species-specific role of SOX2 in regulation of pluripotency

This study uses base editing in bovine embryos to show that SOX2 has species-specific roles in pluripotency regulation, differing from its function in mice.

Linker histone H1FOO is required for bovine preimplantation development by regulating lineage specification and nucleosome assembly

This study shows that H1FOO is essential for bovine preimplantation development by regulating lineage specification and nucleosome assembly, with its depletion causing developmental arrest and chromatin structure changes.

The histone deacetylase activity of HDAC1/2 is required to safeguard zygotic genome activation in mice and cattle

This study shows HDAC1/2 activity is essential for zygotic genome activation in mice and cattle by regulating histone modifications and gene expression during early development.

Essential roles of Hdac1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

This study shows that co-knockdown of Hdac1 and 2 causes developmental failure in mouse embryos due to impaired lineage specification, increased apoptosis, and altered DNA methylation.