Panpan Zhao

This study shows p300/CBP acetylation is essential for minor zygotic genome activation by enabling DUX expression and Pol II pre-configuration at ZGA gene promoters.

This study investigates the role of Tead4 in mouse and bovine preimplantation development, finding it essential for blastocyst formation and regulating key genes like Krt8 and Yap.

This study shows that H1FOO is essential for bovine preimplantation development by regulating lineage specification and nucleosome assembly, with its depletion causing developmental arrest and chromatin structure changes.

This study shows HDAC1/2 activity is essential for zygotic genome activation in mice and cattle by regulating histone modifications and gene expression during early development.

This study shows that co-knockdown of Hdac1 and 2 causes developmental failure in mouse embryos due to impaired lineage specification, increased apoptosis, and altered DNA methylation.