Lei Luo

This study uses base editing in bovine embryos to show that SOX2 has species-specific roles in pluripotency regulation, differing from its function in mice.

This study shows HDAC1/2 activity is essential for zygotic genome activation in mice and cattle by regulating histone modifications and gene expression during early development.

This study shows that co-knockdown of Hdac1 and 2 causes developmental failure in mouse embryos due to impaired lineage specification, increased apoptosis, and altered DNA methylation.