ImmunologybioRxivPreprint
Adenosine impairs T cell function via activation of purine salvage pathway and AMP-induced inhibition of pyrimidine nucleotide biosynthesis
Karolina Losenkova, Ursula J Von Danwitz, Nora Kreisig…·Gennady G. Yegutkin
This study shows adenosine impairs T cell function by activating the purine salvage pathway and inhibiting pyrimidine biosynthesis through AMP-mediated suppression of UMP synthase.
DOI 10.64898/2026.09.07.749884