Adenosine impairs T cell function via activation of purine salvage pathway and AMP-induced inhibition of pyrimidine nucleotide biosynthesis
Karolina Losenkova, Ursula J Von Danwitz, Nora Kreisig, Samuel Svärd, Julia S Baier, Corinna Weiler, Anton V. Zavialov, Neil J. Thomson, Christa E Muller, Osman Gani, Sirpa Jalkanen, Akira Takeda, Gennady G. Yegutkin
This study shows adenosine impairs T cell function by activating the purine salvage pathway and inhibiting pyrimidine biosynthesis through AMP-mediated suppression of UMP synthase.
bioRxiv · Sep 13, 2026 · PreprintImmunology