Molecular BiologyMolecular CellPeer-reviewed
Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition
Renjian Xiao, Shukun Wang, Ruijie Han…·Leifu Chang
This study determines the cryo-EM structure of Cas12k from Scytonema hofmanni complexed with sgRNA and target DNA, revealing mechanisms for PAM sequence recognition and DNA transposition.
53 citations