Author

Renjian Xiao

Purdue University West LafayetteORCID 0000-0002-5914-0812Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Assay:DNA methylation· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Leifu ChangiD· 4 shared Samuel H. SternbergiD· 3 shared Tanner WiegandiD· 3 shared Adriana I. Palmieri· 2 shared Dan Xie· 2 shared Florian T. HoffmanniD· 2 shared Hoang C. LeiD· 2 shared Americo A. Casas-CiniglioiD· 1 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMolecular Biology

Leifu ChangORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 23, 2026

Structural and genetic dissection of RNA-guided gene repression by TnpB-derived transcription factors

Renjian Xiao, Americo A. Casas-Ciniglio, Hoang C. Le…·Samuel H. Sternberg

The paper identifies a TldR repressor in Enterococcus faecalis that directly represses OppA, revealing its role in regulating bacterial peptide import and uncovering a conserved structural mechanism inherited from TnpB ancestors.

DOI 10.64898/2026.09.22.753285

bacteria (other)proteomics

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Molecular BiologyNaturePeer-reviewedMar 4, 2026

Exapted CRISPR-Cas12f homologs drive RNA-guided transcription

Florian T. Hoffmann, Tanner Wiegand, Adriana I. Palmieri…·Samuel H. Sternberg

The paper identifies a novel RNA-guided transcription mechanism using dCas12f and σE factors in E. coli, enabling gene activation without traditional promoter motifs.

7 citationstop 1%

E. coliDNA methylation

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BiochemistryNaturePeer-reviewedMar 4, 2026

Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex

Renjian Xiao, Florian T. Hoffmann, Dan Xie…·Leifu Chang

This study determines cryo-EM structures of the dCas12f-σE-RNAP complex to reveal a novel RNA-guided transcription mechanism in bacteria.

7 citationstop 1%

bacteria (other)cryo-EM

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Molecular BiologyMolecular CellPeer-reviewedAug 26, 2021

Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition

Renjian Xiao, Shukun Wang, Ruijie Han…·Leifu Chang

This study determines the cryo-EM structure of Cas12k from Scytonema hofmanni complexed with sgRNA and target DNA, revealing mechanisms for PAM sequence recognition and DNA transposition.

53 citations

DNA methylationexperimental assay

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