Masahito Hosokawa

A combination of two-enzyme system and enzyme engineering improved the activity of a new PET hydrolase identified from soil bacterial genome

The paper identifies a novel PET hydrolase from soil bacteria, enhances its activity with CALB and protein engineering, achieving 95.5% PET degradation.

Large-scale single-virus genomics uncovers hidden diversity of river water viruses and diversified gene profiles

This study uses a new single-virus sequencing platform to identify diverse viral genomes in river water, revealing novel species and gene transfer patterns.

Reproducible and sensitive micro-tissue RNA-sequencing from formalin-fixed paraffin-embedded tissue for spatial gene expression analysis

This study develops a sensitive RNA-seq method for FFPE tissues to analyze spatial gene expression in tumor microenvironments.

Extensive single-cell genomics reveals bacterial diversity and diverse phage host ranges in the area in and around the Red Sea

The paper develops a single-cell genome sequencing platform, SAG-gel, to analyze microbial diversity in Red Sea environments, revealing 734 partial genomes from 231 species, most of which are newly identified.