Author

Hiroko Matsunaga

Waseda UniversityORCID 0000-0002-1725-3333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Haruko TakeyamaiD· 3 shared Ashok Zachariah SamueliD· 1 shared Ayumi Taguchi· 1 shared Chitose TakahashiiD· 1 shared Daisuke YoshimotoiD· 1 shared Hideki Kambara· 1 shared Hiromi YanagisawaiD· 1 shared Hitoshi IuchiiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMolecular Biology

Haruko TakeyamaORCID

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3 papers

Recent·Most cited

Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans

Kaori Sugiyama, Yuya Sato, Hiroko Matsunaga, Kenichi Kimura, Kosuke Kataoka, Toru Asahi, Hiromi Yanagisawa, Haruko Takeyama

The paper identifies osteopontin (OPN) upregulation as a conserved molecular signature of the pre-rupture state in thoracic aortic aneurysms across mice and humans.

bioRxiv · May 31, 2026 · PreprintMolecular Biology

Integrating spatial and single-cell multi-omics analysis of induced pluripotent stem cell-derived cervical adenocarcinoma model

Saki Kamata, Ayumi Taguchi, Hitoshi Iuchi, Yuji Ikeda, Rie Maruyama, Yoko Nakanishi, Toshihiro Sugi, Yuki Okuma, Osamu Kobayashi, Naoko Tomita, Daisuke Yoshimoto, Lifang Wang, Nozomi Moritsugu, Chitose Takahashi, Michihira Tagami, , Kei Kawana

The paper establishes an HPV18-associated cervical adenocarcinoma model using iRCs and integrates spatial transcriptomics with single-cell multi-omics to identify Gland_A as a key component with specific molecular features.

bioRxiv · May 6, 2026 · PreprintCancer Biology

Reproducible and sensitive micro-tissue RNA-sequencing from formalin-fixed paraffin-embedded tissue for spatial gene expression analysis

Hiroko Matsunaga, Koji Arikawa, Miki Yamazaki, Ryota Wagatsuma, Keigo Ide, Ashok Zachariah Samuel, Kazuya Takamochi, Kenji Suzuki, Takuo Hayashi, Masahito Hosokawa, Hideki Kambara, Haruko Takeyama

This study develops a sensitive RNA-seq method for FFPE tissues to analyze spatial gene expression in tumor microenvironments.

Scientific Reports · Nov 14, 2022Peer-reviewedMolecular Biology