Zengqi Wen

This study identifies Nucleosome Wrapping Domains (NRDs) in mouse ES cells and shows their conservation in yeast and fly, linking nucleosome wrapping to 3D genome organization and DNA replication timing.

This study reveals the structural basis of SUV420H1's recognition and methylation of H4K20 on nucleosomes, showing how H2A.Z enhances its catalytic activity and how mutations affect its function.