Author

Kelly Brewer

Icahn School of Medicine at Mount SinaiORCID 0000-0002-7086-4571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Andrea Elizabeth DunaifiD· 2 shared Ryan K. SiskiD· 2 shared Aarno V. PalotieiD· 1 shared Alejandro BarreraiD· 1 shared Amber A DeVriesiD· 1 shared André Gerardus UitterlindeniD· 1 shared Andres SalumetsiD· 1 shared Anne E. JusticeiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenomics

Andrea Elizabeth DunaifORCID

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2 papers

Recent·Most cited

Gene regulatory activity associated with PCOS revealed DENND1A-dependent testosterone production

Laavanya Sankaranarayanan, Kelly Brewer, Graham D. Johnson, Alejandro Barrera, Revathy Venukuttan, Ryan K. Sisk, Andrea Elizabeth Dunaif, Timothy E. Reddy

The paper identifies gene regulatory mechanisms in PCOS-associated loci, showing DENND1A-dependent testosterone elevation through experimental and genetic analyses.

bioRxiv · May 23, 2024 · PreprintGenomics

Genomic and proteomic evidence for hormonal and metabolic foundations of polycystic ovary syndrome

Loes M E Moolhuijsen, Jia Zhu, Benjamin H. Mullin, Natàlia Pujol‐Gualdo, Ky’Era V. Actkins, Jasmine A. Mack, Hridya Rao, Bhavi Trivedi, Katherine A. Kentistou, Yajie Zhao, David Westergard, Jaakko S. Tyrmi, Guðmar Þorleifsson, Yanfei Zhang, Laura B. L. Wittemans, , Felix R. Day

This study identifies 31 plasma proteins and expands genetic loci associated with PCOS, highlighting metabolic and hormonal influences and polygenic risk effects on cardio-metabolic outcomes.

medRxiv · Apr 18, 2024 · PreprintGenetic & Genomic Medicine