Author

Graham D. Johnson

Duke UniversityORCID 0000-0003-0723-4697Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Timothy E. ReddyiD· 5 shared Alejandro BarreraiD· 4 shared Revathy VenukuttaniD· 2 shared Alejandro OchoaiD· 1 shared Alexias SafiiD· 1 shared Alfonso Buil Demur· 1 shared Allison E. Ashley‐KochiD· 1 shared Andrea Elizabeth DunaifiD· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersGenomics

Timothy E. ReddyORCID

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5 papers

Recent·Most cited

SMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cells

Schuyler M. Melore, D. Dewran Koçak, Keith Siklenka, Graham D. Johnson, Courtney A. Williams, Luke C. Bartelt, Angela G. Jones, Alejandro Barrera, Revathy Venukuttan, Charles A. Gersbach, Timothy E. Reddy

The paper identifies SMARCA2 as a critical cofactor for a subset of glucocorticoid response genes in A549 cells through a CRISPR screen and functional analysis.

bioRxiv · Nov 13, 2025 · PreprintGenomics

The gene regulatory effects of selective glucocorticoid receptor ligands

Nicholas S. Giroux, Graham D. Johnson, Alejandro Barrera, Timothy E. Reddy

The paper evaluates the gene regulatory effects of ten synthetic glucocorticoid receptor ligands using mRNA-seq and STARR-seq, finding their responses correlate with dexamethasone and are not selective to subsets of the molecular GC response.

bioRxiv · Jun 16, 2025 · PreprintGenomics

Gene regulatory activity associated with PCOS revealed DENND1A-dependent testosterone production

Laavanya Sankaranarayanan, Kelly Brewer, Graham D. Johnson, Alejandro Barrera, Revathy Venukuttan, Ryan K. Sisk, Andrea Elizabeth Dunaif, Timothy E. Reddy

The paper identifies gene regulatory mechanisms in PCOS-associated loci, showing DENND1A-dependent testosterone elevation through experimental and genetic analyses.

bioRxiv · May 23, 2024 · PreprintGenomics

Detecting regulatory elements in high-throughput reporter assays

Young‐Sook Kim, Graham D. Johnson, Jungkyun Seo, Alejandro Barrera, William H. Majoros, Alejandro Ochoa, Andrew S. Allen, Timothy E. Reddy

The paper identifies technical biases in STARR-seq data, develops a statistical model to correct them, and improves detection of regulatory elements with better precision and recall.

bioRxiv · Aug 7, 2020 · PreprintBioinformatics

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

Julien Bryois, Melanie E. Garrett, Lingyun Song, Alexias Safi, Paola Giusti‐Rodríguez, Graham D. Johnson, Alfonso Buil Demur, John F. Fullard, Panos Roussos, Pamela B. Sklar, Schahram Akbarian, Vahram H. Haroutunian, Craig A. Stockmeier, Gregory A. Wray, Kevin P. White, , Gregory E. Crawford

The paper evaluates chromatin accessibility in prefrontal cortex samples from schizophrenia cases and controls, finding high heritability enrichment in open chromatin regions but no differential accessibility between groups.

bioRxiv · May 25, 2017 · PreprintGenomics