Single nucleotide variation catalogue from clinical isolates mapped on tertiary and quaternary structures of ESX-1 related proteins reveals critical regions as putative Mtb therapeutic targets
Oren Tzfadia, Axel Siroy, Alexandra Vujkovic, Abril Gijsbers, Jihad Snobre, Roger Vargas, Wim Mulders, Conor Joseph Meehan, Maha Reda Farhat, Peter J. Peters, Bouke Catherine de Jong, Raimond B. G. Ravelli
The paper identifies conserved regions in ESX-1 related proteins by mapping SNVs from MTB isolates onto protein structures, highlighting potential therapeutic targets.
bioRxiv · Jun 22, 2023 · PreprintGenomics