Author

Axel Siroy

Centre National de la Recherche ScientifiqueORCID 0000-0002-8013-3596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Rémi FronzesiD· 2 shared Abril GijsbersiD· 1 shared Alexandra VujkoviciD· 1 shared Anne Caumont‐Sarcos· 1 shared Bouke Catherine de JongiD· 1 shared Carine FromentiD· 1 shared Conor Joseph MeehaniD· 1 shared Dominik GurvičiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

Rémi FronzesORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Structural Basis of Lipopolysaccharide Assembly by the Outer Membrane Translocon Holo-Complex

Haoxiang Chen, Axel Siroy, Violette Morales, Dominik Gurvič, Yves Quentin, Stéphanie Balor, Yassin A. Abuta’a, Maurine Marteau, Carine Froment, Anne Caumont‐Sarcos, Julien Marcoux, Phillip James Stansfeld, Rémi Fronzes, Raffaele Ieva

The paper uses cryo-EM and simulations to reveal how LptM and LptY facilitate LPS transport by modulating LptD conformational dynamics in the translocon complex.

Nature Communications · Nov 24, 2025Peer-reviewedMicrobiology

A ubiquitin-like protein controls assembly of a bacterial Type VIIb secretion system

Gabriel Umaji Oka, Nathanaël Benoit, Axel Siroy, Francesca Gubellini, Esther Marza, Rémi Fronzes

This study presents the cryo-EM structure of a bacterial Type VIIb secretion system core complex, showing how a ubiquitin-like protein coordinates its assembly and function.

Science Advances · Nov 21, 2025Peer-reviewedMicrobiology

Single nucleotide variation catalogue from clinical isolates mapped on tertiary and quaternary structures of ESX-1 related proteins reveals critical regions as putative Mtb therapeutic targets

Oren Tzfadia, Axel Siroy, Alexandra Vujkovic, Abril Gijsbers, Jihad Snobre, Roger Vargas, Wim Mulders, Conor Joseph Meehan, Maha Reda Farhat, Peter J. Peters, Bouke Catherine de Jong, Raimond B. G. Ravelli

The paper identifies conserved regions in ESX-1 related proteins by mapping SNVs from MTB isolates onto protein structures, highlighting potential therapeutic targets.

bioRxiv · Jun 22, 2023 · PreprintGenomics