Peter J. Peters

A human organoid model of alveolar regeneration reveals distinct epithelial responses to interferon-gamma

This study develops a human organoid model to investigate interferon-gamma's effects on alveolar epithelial cell regeneration, showing divergent impacts on AT1 and AT2 cells.

Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets

The paper shows that Invasin-coated plates enable long-term 2D expansion of epithelial organoids from multiple species, offering an alternative to Matrigel/BME.

Ice thickness control and measurement in the VitroJet for time-efficient single particle structure determination

The paper develops a method to measure and control ice thickness in the VitroJet for cryo-EM, improving efficiency in single particle structure determination.

Tuft cells act as regenerative stem cells in the human intestine

The paper identifies four human tuft cell states, showing they function as radiation-resistant stem cells capable of regenerating the intestinal epithelium.

Single nucleotide variation catalogue from clinical isolates mapped on tertiary and quaternary structures of ESX-1 related proteins reveals critical regions as putative Mtb therapeutic targets

The paper identifies conserved regions in ESX-1 related proteins by mapping SNVs from MTB isolates onto protein structures, highlighting potential therapeutic targets.

Mycobacteria-host interactions in human bronchiolar airway organoids

This study uses human airway organoids to model tuberculosis infection, showing mycobacteria infect epithelial cells with low efficiency and the organoid microenvironment controls but does not eliminate the pathogen.