Author

Isabella Lin

University of California, Los AngelesORCID 0000-0002-7102-6879Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Aileen Ning· 2 shared Bianca E. RusselliD· 2 shared Valerie A. ArboledaiD· 2 shared Abigail S. Krall· 1 shared Analeyla Herrera· 1 shared Angela WeiiD· 1 shared Heather R. ChristofkiD· 1 shared Linsey StilesiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Aileen Ning

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Truncating ASXL1 variants rewire cellular metabolism via mitochondrial pyruvate carrier repression

Isabella Lin, Michael Sigfrid S. Reyes, Abigail S. Krall, Neerja Vashist, Suzanna Sarkissian, Nedas Matulionis, Aileen Ning, Linsey Stiles, Bianca E. Russell, Paul Mark B. Medina, Heather R. Christofk, Valerie A. Arboleda

This paper shows that truncating ASXL1 variants disrupt mitochondrial pyruvate transport, leading to metabolic changes and Wnt signaling dysregulation in Bohring-Opitz syndrome and myeloid leukemia.

bioRxiv · Jul 17, 2026 · PreprintGenetics

Truncating ASXL1 mutations in Bohring-Opitz Syndrome dysregulate canonical and non-canonical Wnt Signaling

Isabella Lin, Angela Wei, Zain Awamleh, Meghna Singh, Aileen Ning, Analeyla Herrera, Bianca E. Russell, Rosanna Weksberg, Valerie A. Arboleda

The paper identifies how ASXL1 mutations disrupt the epigenome and activate Wnt signaling pathways in Bohring-Opitz syndrome and myeloid leukemias.

bioRxiv · Dec 15, 2022 · PreprintGenetics