Author

Michael Sigfrid S. Reyes

University of California, Los AngelesORCID 0009-0006-2025-0383Unclaimed ORCID profile · follow to get notified of new preprints

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Genetics· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Abigail S. Krall· 1 shared Aileen Ning· 1 shared Bianca E. RusselliD· 1 shared Heather R. ChristofkiD· 1 shared Isabella LiniD· 1 shared Linsey StilesiD· 1 shared Nedas MatulionisiD· 1 shared Neerja VashistiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Abigail S. Krall

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1 paper

Recent·Most cited

GeneticsbioRxivPreprintJul 17, 2026

Truncating ASXL1 variants rewire cellular metabolism via mitochondrial pyruvate carrier repression

Isabella Lin, Michael Sigfrid S. Reyes, Abigail S. Krall…·Valerie A. Arboleda

This paper shows that truncating ASXL1 variants disrupt mitochondrial pyruvate transport, leading to metabolic changes and Wnt signaling dysregulation in Bohring-Opitz syndrome and myeloid leukemia.

1 citation

humanbulk RNA-seq

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