William Ott

Noisy delay denoises biochemical oscillators

The paper shows that noisy delay in genetic oscillators can improve temporal peak reliability and sharpen oscillation peaks without affecting the period.

Tunable dynamics in a multi-straintranscriptional pulse generator

This paper demonstrates how to tune gene circuit dynamics in a synthetic microbial consortium by adjusting strain fractions, creating a pulse generator with controllable amplitude.

Spatiotemporal dynamics of synthetic microbial consortia in microfluidic devices

This study investigates how trap size in microfluidic devices affects the spatiotemporal dynamics of synthetic microbial consortia, revealing a trade-off between signaling effectiveness and strain proportion stability.

Bayesian inference of distributed time delay in transcriptional and translational regulation

The paper introduces a Bayesian framework to infer reaction rates and delay distributions in biochemical networks using single-cell data, showing robust parameter estimation with limited measurements.

Boundary-Driven Emergent Spatiotemporal Order in Growing Microbial Colonies

The paper introduces a stochastic spatial Moran model to explain spatiotemporal patterns in growing bacterial colonies, showing how boundary effects and cell-cell interactions drive alignment changes.

Modeling mechanical interactions in growing populations of rod-shaped bacteria

The paper presents an agent-based model to simulate mechanical interactions in growing rod-shaped bacterial populations and demonstrates its application in microfluidic traps.