Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms
Meenakshi Suku, Jack F. Murphy, Sara Corbezzolo, Manus Jonathan Paul Biggs, Giancarlo Forte, Irene C. Turnbull, Kevin D. Costa, Lesley M. Forrester, Michael G. Monaghan
This study generates cardiac resident-like macrophages and cardiomyocytes from iPSCs to investigate their interactions in 2D and 3D settings, showing improved cardiomyocyte maturation and function when co-cultured.
bioRxiv · Dec 4, 2024 · PreprintBioengineering