Brianna Chrisman

An Algorithm for Sequence Location Approximation using Nuclear Families (ASLAN) Validates Regions of the Telomere-to-Telomere Assembly and Identifies New Hotspots for Genetic Diversity

ASLAN identifies regions of the human genome missing from GRCh38 and finds new genetic diversity hotspots by analyzing unmapped reads from nuclear families.

Topic modeling for multi-omic integration in the human gut microbiome and implications for autism

This study uses topic modeling to integrate multi-omic data from the gut microbiome of children with and without autism, identifying microbial processes associated with autism.

The Human "Contaminome": Bacterial, Viral, and Computational Contamination in Whole Genome Sequences from 1,000 Families

The paper analyzes contamination in whole genome sequencing data from 1,000 families, identifying bacterial, viral, and computational sources that affect sequencing accuracy.

Transmission Dynamics of Human Herpesviruses and Other Blood DNA Viruses from Whole Genome Sequences of Families

The paper analyzes whole genome sequences of families to study the human blood DNA virome, finding evidence of household transmission and de novo viral integration.

A Computational Modeling Framework to Analyze Synovial-Tissue Based Drug Targets and Diagnostic Biomarkers in Rheumatoid Arthritis

This study uses computational modeling to identify potential drug targets and diagnostic biomarkers in rheumatoid arthritis by analyzing gene network interactions and pathway perturbations.

Structural Variants in SARS-CoV-2 Occur at Template-Switching Hotspots

The paper identifies structural variants in SARS-CoV-2 sequences and links them to recombination events and template-switching hotspots.