Dennis Paul Wall

An Algorithm for Sequence Location Approximation using Nuclear Families (ASLAN) Validates Regions of the Telomere-to-Telomere Assembly and Identifies New Hotspots for Genetic Diversity

ASLAN identifies regions of the human genome missing from GRCh38 and finds new genetic diversity hotspots by analyzing unmapped reads from nuclear families.

The Contributions of Rare Inherited and Polygenic Risk to ASD in Multiplex Families

This study identifies 74 ASD risk genes using whole genome sequencing of multiplex families and finds polygenic risk interacts with rare inherited variants.

Topic modeling for multi-omic integration in the human gut microbiome and implications for autism

This study uses topic modeling to integrate multi-omic data from the gut microbiome of children with and without autism, identifying microbial processes associated with autism.

The Human "Contaminome": Bacterial, Viral, and Computational Contamination in Whole Genome Sequences from 1,000 Families

The paper analyzes contamination in whole genome sequencing data from 1,000 families, identifying bacterial, viral, and computational sources that affect sequencing accuracy.

Transmission Dynamics of Human Herpesviruses and Other Blood DNA Viruses from Whole Genome Sequences of Families

The paper analyzes whole genome sequences of families to study the human blood DNA virome, finding evidence of household transmission and de novo viral integration.

Enrichment of genomic variation in pathways linked to autism

The paper reanalyzes genomic studies of autism using prior knowledge to identify 68 significant biological concepts linked to autism, suggesting their importance in the disease's genetic basis.

Structural Variants in SARS-CoV-2 Occur at Template-Switching Hotspots

The paper identifies structural variants in SARS-CoV-2 sequences and links them to recombination events and template-switching hotspots.

Whole genome sequencing in multiplex families reveals novel inherited and de novo genetic risk in autism

This study uses whole-genome sequencing in multiplex families to identify novel inherited and de novo genetic risk factors for autism, revealing 16 new ASD-risk genes and supporting 69 total genes.

Refining the role of de novo protein truncating variants in neurodevelopmental disorders using population reference samples

The paper shows that many de novo protein truncating variants in neurodevelopmental disorders are common in population cohorts and do not contribute to risk, using data from 9246 families and 60,706 adults.