Vincent J. Hilser

Multivalent weak contacts shape chaperone-nascent protein interactions

This study uses single-molecule techniques to show that trigger factor interacts with nascent proteins via multiple weak, dynamic contacts that evolve during elongation.

Chaperone saturation mediates translation and protein folding efficiency

The paper shows that chaperone saturation limits protein folding homeostasis when translation efficiency is high, revealing mutual sensitivity between translation and folding efficiency.