Pharmacology & ToxicologyBiomedicine & PharmacotherapyPeer-reviewed
NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity.
James A. Roberts, Michael Batie, Amy H. Ponsford…·Parveen Sharma
This study shows that CDDO-Me activates NRF2 to protect AC16 human cardiomyocytes from doxorubicin-induced toxicity by modulating p53 signaling, apoptosis, and ferroptosis.
DOI 10.1016/j.biopha.2025.118878