Patient-Derived Melanoma Organoids Preserve Tumor-Immune Heterogeneity and Reveal Context-Dependent Responses to Immune Checkpoint Blockade
Mamatha Serasanambati, Jay Chadokiya, Michitaka Nakano, Maximilian Julve, Pauline Funchain, Saurabh Sharma, Emma Wagner, Prabhjeet Singh, Calvin Jay Kuo, Allison Betof Warner, Amanda Kirane
This study establishes patient-derived melanoma organoids (PDMOs) that retain tumor-immune heterogeneity and show context-dependent responses to immune checkpoint blockade.
bioRxiv · Sep 29, 2026 · PreprintImmunology